No strong head-to-head trials comparing atorvastatin and simvastatin have been conducted. However, atorvastatin is considered a more potent drug than simvastatin. In one recent comparative study, atorvastatin was found to be more effective at lowering LDL cholesterol (LDL-C) than simvastatin.
Which statin has the strongest efficacy for lowering LDL?
Similarly, data from comparative trials, shown in Table 1 confirm that rosuvastatin is the most effective statin for lowering LDL-C (reduction of 63% with 40 mg daily), followed by atorvastatin, simvastatin, and pravastatin.
Is Vytorin better than atorvastatin?
Additional results from the study showed that VYTORIN 10/40 mg decreased LDL cholesterol by 59 percent compared to 48 percent for Lipitor 40 mg in the subgroup of high risk patients. These patients had a baseline LDL cholesterol values of 169 mg/dL and 175 mg/dL respectively (p<0.001).
Is atorvastatin stronger than simvastatin?
Dose for dose, atorvastatin is more potent than simvastatin at blocking the target enzyme, HMGCoA; this effect is overcome by using a higher dose of simvastatin. In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective.
Can I switch from atorvastatin to simvastatin?
A large proportion of patients who switch from atorvastatin to simvastatin are prescribed doses that are not therapeutically equivalent, and these patients were significantly less likely to meet LDL-C treatment goals compared with patients who remained on atorvastatin.
What is the difference between atorvastatin and simvastatin?
What is the best and safest statin to take?
Simvastatin and pravastatin had the best safety profile, according to this review. Overall, the researchers found a 9 percent increased risk of type 2 diabetes in people taking statins.
Is Vytorin the same as simvastatin?
Vytorin generic Vytorin is a brand-name drug that contains two active drugs: ezetimibe and simvastatin. This combination of active drugs is also available as a generic drug called ezetimibe/simvastatin. A generic drug is an exact copy of the active drug in a brand-name medication.
In summary, atorvastatin is more effective, at lower doses than simvastatin for treating cases of severe hyperlipidaemia but this comes at the price of a possible increase in side-effects and fibrinogen, reduced HDL at 80 mg and a lesser reduction in Lp(a).
What are the possible side effects of simvastatin?
headache;
Is Crestor better than atorvastatin?
Crestor appears as effective as atorvastatin at lowering cholesterol; however, grapefruit products do not affect Crestor to the same extent as atorvastatin. People of Asian descent may be more… Lipitor is effective at lowering cholesterol; however, its use may be limited by side effects such as muscle pain.
How effective is simvastatin?
Clinical Studies in Adults. Simvastatin significantly slowed the progression of lesions as measured in the Year 4 angiogram by both parameters, as well as by change in percent diameter stenosis. In addition, Simvastatin significantly decreased the proportion of patients with new lesions and with new total occlusions.
