Hereditary motor sensory neuropathy (HMSN), also known as Charcot-Marie-Tooth Disease, is an inherited, progressive disease of the nerves with weakness and numbness more pronounced in the legs than the arms.
What causes axonal polyneuropathy?
Diabetes, HIV infection and alcoholism can cause several patterns of neuropathy. They most commonly cause a distal, symmetric axonal sensorimotor neuropathy. The second most common presentation in these conditions is a small-fiber, painful neuropathy.
What causes axonal nerve damage?
Axonal neuropathy, a characteristic feature of this condition, is caused by damage to a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses.
Is CMT a myopathy?
Charcot-Marie-Tooth (CMT) hereditary neuropathy refers to a group of disorders characterized by a chronic motor and sensory polyneuropathy, also known as hereditary motor and sensory neuropathy (HMSN)….Table 1.
| Gene 1 | MT-ATP6 |
|---|---|
| MOI | mt |
| Disorder | NARP |
| Other | Neurogenic muscle weakness, ataxia, & retinitis pigmentosa |
Is CMT autoimmune?
The phenotypic features encompasses neurological alterations similar to those observed in the axonal type 2 form of Charcot-Marie-Tooth disease (CMT2) and include autoimmune manifestations.
Can CMT skip a generation?
If a woman with the defective X chromosome only has daughters, CMT can skip a generation until one of her grandsons inherits it.
Is Charcot-Marie-Tooth autoimmune?
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