What is Burkholderia cepacia infection?

Burkholderia cepacia, or B. cepacia, is a group of bacteria found in soil and water. It can cause serious respiratory infections in patients who are susceptible to illness. Several non-respiratory B. cepacia outbreaks have been linked to contaminated medical products.

What disease is caused by Burkholderia cepacia?

Burkholderia cepacia is a plant phytogen and is known as a hardy and versatile organism. Over the past two decades it has emerged as a pathogen in the cystic fibrosis (CF) community, with devastating effects. Pulmonary colonisation can lead to an accelerated decline in lung function.

Can a healthy person get B. cepacia?

Populations susceptible to B. cepacia poses little medical risk to healthy people. However, people who have certain health problems like weakened immune systems or chronic lung diseases, particularly cystic fibrosis , may be more susceptible to infections with B. cepacia.

Is Burkholderia cepacia pneumonia?

Burkholderia cepacia is a gram-negative bacilli leading to pneumonia with poor prognosis and usually seen in patients with immunosuppression or with structural lung diseases.

Is Burkholderia cepacia Anaerobic?

Burkholderia cepacia is an aerobic gram-negative bacillus found in various aquatic environments. B cepacia is an organism of low virulence and is a frequent colonizer of fluids used in the hospital (eg, irrigation solutions, intravenous fluids).

Is Burkholderia cepacia motile?

B. cepacia is a motile organism, and motility is mediated by polar flagella (3, 21). Little is known about the structure and function of B. cepacia flagella, although attempts to type strains based on the elaborated flagellin protein have been made.

What are the symptoms of Burkholderia cepacia?

The symptoms of B. cepacia, if any, are the same as those for any lung infection and can include fever, cough, congestion, shortness of breath, and wheezing.

Is Burkholderia cepacia contagious?

Research has shown that people with CF can get B. cepacia from others who are infected with these bacteria. The germs spread either by direct contact, such as kissing, or indirectly from touching objects with the germs, such as doorknobs.

How do you test for Burkholderia cepacia?

To test for Burkholderia, ARL Bio Pharma prepares enrichment media (Tryptic Soy Broth), along with a specialized Burkholderia cepacia Complex Selective Agar. This special agar inhibits non-Burkholderia organisms, and changes color to indicate the likely presence of the target microorganisms.

What kills Burkholderia cepacia?

The antibiotics polymyxin, gentamicin and vancomycin are used at high concentrations in B. cepacia Selective Agar, a highly effective medium for their isolation from CF sputum.

Is Burkholderia cepacia a coliform?

Burkholderia cepacia complex (BCC), or simply Burkholderia cepacia, is a group of catalase-producing, lactose-nonfermenting, Gram-negative bacteria composed of at least 20 different species, including B. cepacia, B….

What is Burkholderia cepacia precautions?

Administer Contact and Droplet precautions for patients with B. cepacia complex, multiple drug resistant P. aerugenosa and MRSA. Avoid activities & risk factors associated with transmission of pathogens.

How many bacteria are in Burkholderia cepacia?

MICROBIOLOGY The taxonomy of Burkholderia (formerly Pseudomonas) cepacia complex currently consists of 18 distinct bacterial species with a wide environmental distribution in soil and plants, especially the underground stem (rhizome) (Table 1) (63, 73).

What is B cepacia classified as?

General Information about B. cepacia. Burkholderia cepacia [burk-hōld–er–ee-uh si–pay–shee–uh] (also called B. cepacia) is the name for a group or “complex” of bacteria that can be found in soil and water. B. cepacia bacteria are often resistant to common antibiotics.

How many operons does Burkholderia cepacia genomovar have?

The Burkholderia cepacia type- strain ATCC 25416 (genomovar I) is 8.1 Mb in length and is known to have four circular replicons. Its largest replicon contains 4 rrn operons and the other two megabase- sized replicons contain a single rrn operon each.

Does cefoperazone/sulbactam work against B cepacia complex?

The antibacterial activity of cefoperazone/sulbactam is comparable to that of ceftazidime against B. cepacia complex and both compounds are more active than cefepime or cefaperazone ( 22 ). Meropenem and doripenem have greater activity in vitro against B. cepacia complex than imipenem or ertapenam ( 11 , 12 , 67 ).