Bullous systemic lupus erythematosus (BSLE) is a rare autoimmune blistering disorder that typically manifests as an acute vesiculobullous eruption in a patient with known systemic lupus erythematosus (SLE). Rarely, BSLE is the initial clinical manifestation of SLE.
What drugs can cause bullous pemphigoid?
Prescription drugs that may cause bullous pemphigoid include etanercept (Enbrel), sulfasalazine (Azulfidine), furosemide (Lasix) and penicillin. Light and radiation. Ultraviolet light therapy to treat certain skin conditions may trigger bullous pemphigoid, as can radiation therapy to treat cancer.
What is bullous systemic lupus erythematosus?
Bullous Systemic Lupus Erythematosus (BSLE) is a rare manifestation of Systemic Lupus Erythematosus (SLE), characterized histologically by subepidermal bullae with predominantly neutrophilic infiltrate and immunoglobulin (IgG, IgA, IgM) and C3 deposition at the basement membrane zone.
What is the prognosis of systemic lupus erythematosus (SLE)?
Fortunately, unlike epidermolysis bullosa acquisita, treatment with dapsone is successful in most cases of bullous systemic lupus erythematosus. The disorder frequently resolves spontaneously in less than 1 year. In some cases, postinflammatory hypopigmentation may remain.
What causes subepidermal blister formation in systemic lupus erythematosus (SLE)?
Subepidermal blister formation in the course of severe systemic lupus erythematosus (SLE) can occur due to extensive interface inflammation and basal cell vacuolation, presenting as polycyclic erosions with advancing blistering border predominantly on sun-exposed areas.[ 1] In contrast, bullous systemic lupus erythematosus (BSLE)…
What is the autoantibody repertoire of systemic lupus erythematosus (SLE)?
The autoantibody repertoire of systemic lupus erythematosus can include nonpathogenic and pathogenic anti-BMZ antibodies.
