Embryonal carcinomas are highly malignant due to continued proliferation of undifferentiated cell populations. The reported testicular neoplasm metastasized to sublumbar and periaortic lymph nodes, the parietal pleura, mediastinum, lung and heart.
What causes embryonal carcinoma?
The most accepted theory on the development of germ cell tumors involves an initiating event that causes fetal gonocytes to undergo abnormal cell division. As with other germ cell tumors, with the exception of spermatocytic seminoma, embryonal carcinomas are believed to originate from intratubular malignant germ cells.
How is embryonal carcinoma treated?
The useful therapeutic modalities are pre-orchiectomy test dose of x-rays, orchiectomy, retroperitoneal lymph node dissection, postoperative irradiation of retroperitoneal nodes, and chemotherapy.
What is an embryonal cell?
(em-BRY-uh-nul TOO-mer) A mass of rapidly growing cells that begins in embryonic (fetal) tissue. Embryonal tumors may be benign or malignant, and include neuroblastomas and Wilms tumors.
Is embryonal carcinoma genetic?
Embryonal carcinoma was found to have a six-gene signature which was detected in 3 of 5 studies and included DNMT3B, DPPA4, GAL, GPC4, POU5F1, and TERF1. All six genes play important roles in embryonic development and pluri-potency, which is the evidence that embryonic carcinoma resembles inner cell mass.
What is difference between seminoma and Dysgerminoma?
A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. A tumor of the identical histology but not occurring in the ovary may be described by an alternate name: seminoma in the testis or germinoma in the central nervous system or other parts of the body.
What is embryonal tumor?
(em-BRY-uh-nul TOO-mer) A mass of rapidly growing cells that begins in embryonic (fetal) tissue. Embryonal tumors may be benign or malignant, and include neuroblastomas and Wilms tumors. Also called embryoma.
What is embryonal sarcoma?
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare form of liver cancer that occurs mainly in children, usually between ages 5 and 10, but also well into adolescence. It is the third most common type of primary liver cancer in kids, after hepatoblastoma and hepatocellular carcinoma.
