Uterine serous carcinoma is an uncommon form of endometrial cancer that typically arises in postmenopausal women. It is typically diagnosed on endometrial biopsy, prompted by post-menopausal bleeding.
What is uterine serous carcinoma?
Uterine serous carcinoma (USC) is an aggressive variant of endometrial cancer that has not been well characterized. It accounts for less than 10% of all endometrial cancers and 80% of endometrial cancer–related deaths.
What is high grade serous carcinoma of the endometrium?
High-grade endometrial carcinomas are a heterogeneous group of clinically aggressive tumours. They include FIGO grade 3 endometrioid adenocarcinoma, uterine papillary serous carcinoma (UPSC), clear cell carcinoma, undifferentiated carcinoma and carcinosarcomas or malignant mixed Mullerian tumour (MMMT).
How bad is serous carcinoma?
Uterine serous carcinoma (USC) accounts for 10% of all endometrial cancer; however, it carries the poorest prognosis, with 5-year survival rates as low as 55% [13].
How is serous carcinoma treated?
Treatment for uterine papillary serous carcinoma generally involves surgery, followed by radiation and chemotherapy. Most often, surgery includes removal of the uterus (hysterectomy), fallopian tubes and ovaries, as well as any other cancer that may be visible in the abdomen during surgery.
Where does uterine serous carcinoma spread?
Background: Uterine papillary serous carcinoma (UPSC) is a highly malignant form of endometrial cancer with a high propensity for metastases and recurrences even when there is minimal or no myometrial invasion. It usually metastasizes to the pelvis, retroperitoneal lymph nodes, upper abdomen, and peritoneum.
Which immunohistochemical findings are characteristic of endometrial serous carcinoma?
Comment: Immunohistochemical stains show that the tumor is positive for p53 (strong and diffuse, mutated) and p16 (strong and diffuse), focally positive for ER and negative for PR. This immunoprofile supports the above diagnosis. Endometrial serous carcinoma (0.8 cm) with superficial myometrial invasion (see synoptic report and comment)
What is uterine serous carcinoma (USC) endometrial cancer?
Uterine serous carcinoma (USC) comprises up to 10% of all primary endometrial cancers and has an aggressive clinical course in comparison to UEC. Monica Prasad Hayes,
What is serous endometrial intraepithelial carcinoma?
Serous endometrial intraepithelial carcinoma: replacement of the surface epithelium or preformed endometrial glands with serous carcinoma without invasion of underlying stroma ( Adv Anat Pathol 2004;11:117 ) Typically postmenopausal, nonobese women, estrogen independent ( Adv Anat Pathol 2004;11:117 )
What is the role of adjuvant therapy for uterine serous carcinoma?
A retrospective multi-institutional study by Dietrich and colleagues found that adjuvant therapy with carboplatin and paclitaxel was associated with improved OS and decreased recurrences. 139 Patients with stage II uterine serous carcinoma have an even higher risk of recurrence.
